Works effectively on stress and fear associated with thunderstorms, wind storms or loud noises. Formulated specifically for dogs 20 to 80 pounds. Works within 5 to 10 minutes in most cases. Stops hiding, barking, panting, shaking or clinging as a result of the storm. Shown to be over 95% effective even when the storm has come. Will not drug or change animals personality just relieves the fear. Will not interact with any other medication.